منابع مشابه
Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.
Polyaspartic Acid (PAA) protects the kidney from experimental gentamicin nephrotoxicity despite large increases in renal cortical gentamicin content. In these experiments, prominent cytoplasmic vacuoles were noted in all animals that received PAA with or without gentamicin. The present study showed that there were no renal structural or functional consequences of PAA given alone or with gentami...
متن کاملPolyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.
We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.
متن کاملPharmacologic limits of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
Polyaspartic acid (PAA) ameliorates experimental gentamicin nephrotoxicity despite marked accumulation of gentamicin in the renal cortex. The experiments described here probe the extent of PAA's nephroprotective action when increasing doses of gentamicin, in excess of an established nephrotoxic dose (40 mg/kg of body weight per day), are administered. After 10 days, virtually complete nephropro...
متن کاملDuration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in n...
متن کاملPolyaspartic Acid Based Superabsorbent Gels with Different Cross-Linkers- A Comparative Study
Two cross-linkers with different functional groups amide (N,NMethylenebisacrylamide (NMBA)) and esters (Ethylene Glycol Dimethylacrylate (EGDMA)) have been selected for comparative study for crosslinking polyaspartic acid (PAsp) and acrylic acid (AA). Thus, resulting in formation of different polymers with PAsp and acrylic acid in different ratios and cross-linked with different cross-linkers. ...
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ژورنال
عنوان ژورنال: Kobunshi
سال: 2001
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.50.393